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The complex polysaccharides of Aloe have been reported to improve immunity and oxidative status either in vitro or in vivo studies. Further, β-carotene has been shown to influence immune function and health in the cow. In this study, the effects of VigoorsanTM, a commercial supplement containing Aloe arborescence and β-carotene, on biochemical profile and oxidative/inflammatory status, were evaluatedin pregnant buffalo cows. VigoorsanTM was supplied (50 g/day/head) to pluriparae buffalo cows for 30 days before delivery. A significant increase of BAP and OXY and a decrease of d-ROMs (P<0.01) were detected in blood from cows supplemented with VigoorsanTM. Further, a decrease of TNF-α, IL1-βand MCP-1 and an increase of IL-10 were showed (P<0.01). Blood chemistry profiles showed no adverse effects on health status. Results showed that VigoorsanTM supplementation improves oxidative and inflammatory status with no negative effects on metabolism in water buffalo cow.